ISSN: 7027-2221

Keywords : T cell


Effect of gender , aging , smoking and urinary tract infections on level of CD4+ T lymphocytes in hypertensive patients treated with propranolol and captopril drugs

Nidhal abdul mohaimen; Arif sami; Zainab Thamer showait al-assady; Ali jalil ali

karbala journal of pharmaceutical sciences, Volume 4, Issue 5, Pages 69-80

Forms of adaptive response may be useful markers of endothelial activation and local or systemic inflammation. In this study the CD4+ T lymphocytes were evaluated during vascular disease like hypertension and the effect of other factors like sex, aging , smoking , anti hypertension drugs treatment (mainly with some β-blockers or angiotensin converting enzyme inhibitors) and urinary tract infections on expression of the CD4+ T lymphocytes were also studied . The results showed that mean level of CD4+ T lymphocytes was increased in hypertensive patients (p≤ 0.01) and this increase is more in female compared to male . Level of CD4+ T lymphocytes was significantly elevated in hypertensive subjects with age group of 30-40 years and the level started to decreased with aging. However, upon treatment with antihypertensive drugs (mainly β-blocker or angiotensin enzyme inhibitors) the level of CD4+ T lymphocytes was reported to decreased . CD4+T lympho-cytes level was significantly increased in hypertensive smoking patients(P ≤ 0.01) and in patients suffering from urinary tract infections (UTIs) .