karbala journal of pharmaceutical sciences

Reaction of different substi tuents of 2-azobenzothiazolyl 4-phenols (I) with ethyl 2-bromo propionate to produce the derivatives (II) that react with thiosemicarbazide gave N-substituted thiosemicarbazide (III) also react with semicarbazide and which gave N-substituted semicarbazide (IV). The 1,2,4-triazole derivatives (V) and 1,3,4- thiadiazole derivatives (VI) were prepared by the cyclization of N-substituted thiosemicarbazide (III) with base and with concentrated sulphuric acid respectively . The 1,3,4-oxadiazole derivatives (VII) were prepared by the cyclization of N-substituted semicarbazide (IV) with acid. the new compounds were established on the basis of IR, 1H NMR and UV spectral data.

A new compounds of 2-amino-5-(m-nitro phenyl)-1,3,4-oxadiazole [1] and 2-amino -5- phenyl-1,3,4-oxadiazole[2], N[(o-hydroxy benzylidene-5-( phenyl-2-yl)-1,3,4-oxadiazole-2-amine][3] or N[(m-nitro benzylidene-5-(m-nitro phenyl-2-yl)-1,3,4-oxadiazole-2-amine][4], 2-(m-nitro phenyl) -3 (5-m-nitrophenyl)1,3,4-oxadiazole]-2-yl-thiazolidin-4-one [5], 2-(m-nitro phenyl) –tetrazolo-1-yl)- 5-(m-nitrophenyl )1,3,4-oxadiazole ] [6] , 5-(m-nitro phenyl)-2/-(m-nitrophenyl)-2-yl-2,3-dihydro-1,3-oxazpine-4,7-dione [7] , 4-hydrazino nicotinic acid [8], 1-phenyl-4-(nicotinoyl) thiosemicarbazide [9], and 3-hydrazino-5- (pyridyl )-1,2,4- Triazole-4-phenyl [11], 3-(p-N,N/ dimethyl amino benzylidene)- hydrazino -5- (pyridyl )-1,2,4- Triazole-4-phenyl [12], 4-(3-methyl pyrazol-5-one)- hydrazino -5- (pyridyl )-1,2,4- Triazole-4-phenyl [13], 4-(3,5-dimethyl pyrazol)- hydrazine-5- (pyridyl )-1,2,4- Triazole-4-phenyl [14], ethyl 4-bromo-phenoxy acetate [15], p-bromo pheno -aceto thiosemicabazone [16] ,2- amino-5-[(p-bromp phenoxymethylene)-1,3,4-thiadiazole [17], 2N( p-nitro benzylidene)-1,3,4-Thiadiazole -5- (p-bromo phenoxy methyl [1 8 ], 5 -(p-bromo phenoxy methyl) 2/-(p-nitro phenyl- 2-yl)-5,6-dimethyl-1,3-oxazpine-4,7-dione [19] or5-(p-bromo phenoxy methyl) 3-(p-nitro phenyl- 2-yl)-2,3-dihydro-1,3-oxazpine-4,7-dione [20] and imidazoline[21].
The chemical structures of these compounds were identified by FT-IR,H-NMR , Uv spectroscopy and the reaction time ,purity was checked by TLC with determining the melting points. Some of the new compounds were tested against four strains of bacteria ( Klebsiella Pneumoniae ,Pseudomonas aeuroginosa ,Staphylococcus Aureus and Bacillus subtilus ) comparing these activities with that of starting material

A series of compounds of p-Nitro ethyl benzoate [2],p-Nitro benzoic hydrazide [3], 1-phenyl-4-(p-nitrophenyl) thiosemicarbazide [4], 3-mercapto-4-phenyl-5- (p-nitro phenyl)-1,2,4- Triazole[5], 3-hydrazino -4-phenyl-5- (p-nitro phenyl)-1,2,4- Triazole [6], 3-( substituted benzylidene hydrazine)-4-phenyl-5- (p-nitro phenyl-2-yl)-1,2,4-triazole [7] and [8], 2-(substituted aryl)-3-(p-nitrophenyl)-2-yl)-2,3-dihydro-1,3-oxazpine-4,7-dione.[9] and [10], 2-(substituted aryl)-3-(p-nitrophenyl)-2-yl-2,3-benzo-1,3-oxazpine-4,7-dione [11] and [12], 2-(substituted aryl) –tetrazolo-1-yl)-[(3-hydrazino-4-phenyl)- 5-p-nitrophenyl)1,2,4-triazole ] [9], 2-substituted aryl-3~-[3-hydrazino—4-phenyl-5-(p-nitrophenyl)1,2,4-triazole]-2-yl-thiazolidin-4-one [15] and [16]. 2-(substituted aryl) –3-[3-hydrazino—4-phenyl-5-(p-nitrophenyl)1,2,4-triazole]-2-yl-imidazolidin-4-one [17]and [18] were prepared and the chemical structures of these compounds were characterized by FT-IR , 1H-NMR for some of them Uv/vis spectra , C.H.N analysis ), melting points and the purity was checked. Biological activity of these compounds was evaluated.

A new series of heterocyclic compounds including four, five and seven member rings have been synthesized. These compounds including N,N'-(1,4-phenylenebis(methan-1-yl-1-ylidene))bis(substituted) [1,2], ,4(1,4 phenylene)bis(3-chloro-1-(alkyl)azetidine -2-one(3,4) , 1,4-bis(1-(substituted)-2,5-dihydro-1H-tetrazole-5-yl)benzene (5,6), 2,2-(1,4-phenylene)bis(3-(alkyl)-2H benzo[1,3]thiazine-4(3H-one)(7,8). 2,2-(1,4-phenylene)bis(3-(alkyl)-2,3-dihydroquinazoline-4(1H)one)(9,10). thiazepine derivatives(11,12). (5z,5z)-2,2-(1,4-phenylene)-2,3dihydro-1,3-oxazepine-4,7-dione (13,14) and 3,3-(1,4-phenylene)bis(4-(alkyl)-3,4-dihydrobenzo[1,3]oxazepine-1,5-dione(15,16,17,18) . The structures of these compounds characterized by (FT-IR, H-NMR) spectroscopy and C.H.N analysis ,melting points and checked through T.L.C. The biological activity of these compounds was tested against
Staph. Aureus, E. coli , Sal. typhi and Ps. Aerugenosa bacteria.