ISSN: 7027-2221

Keywords : paracetamol


CLINICAL ASSESSMENT OF TRAMADOL ANALGESIC EFFECT IN COMPARISON TO COMBINATION OF PARACETAMOL AND CHLORZOXAZONE IN ACUTE NEUROPATHIC PAIN IN IRAQI PATIENTS

Alaa A. Ali

karbala journal of pharmaceutical sciences, Volume 5, Issue 8, Pages 124-134

Neuropathic pain (NP) is pain initiated or caused by a primary lesion or dysfunction in the nervous system. Many common diseases, injuries, and interventions cause NP by producing lesions in somatosensory pathways in the peripheral or central nervous system. Its treatment is complex with often inadequate response to treatment. Tramadol has been considered as the analgesic of choice for patients in moderate to severe pain and used as a control treatment. Combination of the skeletal muscle relaxant chlorzoxazone and the non-opioid analgesic paracetamol was investigated for their efficacy of blocking NP in comparison with the control treatment. Forty eight patients with age range 20-40 years old (27 males and 21 females) who were treated for acute neuropathic pain in Dijlah rehabilitation hospital were involved. The efficacy of treatment was assessed using 0-10 numeric pain scale. The safety issue of drugs was assessed by investigating liver function test, serum creatinine and hematological parameters. The results revealed that there is no statistical difference (p≥ 0.05) in pain treatment efficacy between the investigated treatment and the control group. The safety issue showed that there is no statistical difference (p≥ 0.05) between the measurement of laboratory data before and after time schedule of the treatment. It is concluded that chlorzoxazone / paracetamol combination therapy is an effective and safe treatment for neuropathic pain comparable to tramadol.

Hepatoprotective effect of green tea (Camellia sinensis) on female rats drenched with paracetamol

Shatha hussein kadhim; Amal Umran Mosa; Mazin Hamid Ouda

karbala journal of pharmaceutical sciences, Volume 4, Issue 6, Pages 110-116

Hepatotoxicity is an acute adverse effect of paracetamol overdose which could be fatal, so in this research we studied the effect of paracetamol on liver enzymes (GPT, GOT, total protein , glucose ,uric acid ) of female rats that drenched green tea. twenty laboratory female rats housed in plastic cages in animal house at Karbala university/ college of pharmacy , the animals divided randomly into five groups ,(G1 control, G2 drenched with 300 mg/kg green tea and 500 mg/kg paracetamol, G3 drenched with 500 mg/kg green tea and 500 mg/kg paracetamol , G4 drenched with 500 mg/kg paracetamol ,G5 drenched with 500 mg/kg green tea ) , the present study found the ability of green tea to protect liver enzyme against the poisonous effect of paracetamol by reducing the higher value of GPT,GOT, Glucose, and evaluated the lower value of Uric acid and total protein causing by paracetamol.

EFFECT OF PARACETAMOL ON SALIVA α-AMYLASE

Othman R. Hameed Alsamarrai

karbala journal of pharmaceutical sciences, Volume 2, Issue 2, Pages 257-263

The effect of paracetamol on the activity of saliva α-amylase was carried out. We prepared three different concentrations solutions of paracetamol (300, 500, 750) mg/100ml. The effect of different volumes (5, 10, 20, 30, 50) µl of paracetamol for each concentration were study. The results showed that paracetamol has inhibition effect on the activity of α-amylase enzyme and highest inhibition at 10µl of inhibitor, while the degree of inhibition for three different concentrations were (52.30, 54.34, 20.70) % respectively. Also, kinetic of enzyme showed km value 1.428 mmol/L, and Vmax value 30303.03 mol.liter-1.min-1, the result showed that inhibition is uncompetitive type.