ISSN: 7027-2221

Keywords : Chitosan

Erectile Dysfunction in Diabetic Patients in the Holy Kerbala/Iraq in 2018

karbala journal of pharmaceutical sciences, Volume 9, Issue 15, Pages 1-10

Erectile dysfunction affects more than 50% of diabetic patients and results in miserable
couple’s life, especially for young adults. Possible predictors are proper therapy and
patient’s compliance with treatment, in addition to the warning signs and symptoms of
sensory neuron and motor deficits. Therefore, this study was conducted to determine the
prevalence of Erectile dysfunction and its predictors among diabetic patients in Kerbala.
Material and methods
The study included a convenient sample of 61 patients with diabetes mellitus type I and II.
They were chosen through a systematic sampling among patients at the diabetes mellitus
clinic at Al Hussein Teaching Hospital in Holy Kerbala /Iraq in 2018. All participants
were interviewed using standard questionnaire. Analysis of data used descriptive and
analytic tools including t-test, chi-square test, logistic regression and structural Equation
modeling through the statistical Package of social sciences and Amos and Excel software
at a significance level of


diabetes mellitus
erectile dysfunction
Autonomic changes
sensory and motor changes
glycemic control.

Study the Effect of Polymer Types on Preparation and in-vitro Evaluation of β-sitosterol as a Topical Hydrogel

karbala journal of pharmaceutical sciences, Volume 9, Issue 15, Pages 32-48

Beta sitosterol is a non-cholesterol sterol, or neutral sterol applied locally for
the treatments of acute and chronic ulcers of skin and mucous membranes as well as
post operative wounds. In this work β –sitosterol was prepared as topical hydrogel by
cold mechanical method using different types of gel-forming polymers such as
chitosan (4%, 3%, and 2%) W/W, carbapol (1.5%, 1%, and 0.5%) , and poloxamer
407( 30% and 25%)W/W. Physicochemical properties of all the prepared formulas
were evaluated as a visual inspection, determination of pH, and spreadability, in
addition to an in-vitro drug release.
The obtained results indicated that all the different concentrations of each
polymer gave a percent of drug release profile inversely proportional with the
polymer concentration. F8 which contain poloxamer 407 at 25% produced higher
drug release than other formulas (100% β-sitosterol release withim 3 hrs).
Based on overall result, β-sitosterol can be successfully prepared as a topical hydrogel
using 25% poloxamer as the best prepared formula.البيتاسايتوسترول هو ستيرول غير الكولسترول ، أو ستيرول محايد تطبيقه محليا لعلاج القرحة الحادة
والمزمنة من الجلد والأغشية المخاطية وكذلك الجروح ما بعد العملية. في هذا العمل ، تم تحضير
البيتاسايتوسترول علىشكل هلام مائي موضعي باستخدام طريقة ميكانيكية باردة باستخدام أنواع مختلفة من
1٪ ، و 0.5 ٪) ، و البوليكزامر ، ٪ 2٪) ، الكاربول ( 1.5 ، ٪3 ، ٪ البوليمرات المكونة للهلام مثل الكيتوسان ( 4
%25 ) و مع تركيز مختلف لكل منهما. تم تقييم الخواص الفيزيائية الكيميائية لجميع الصيغ ,%30 ) 407
المعدة على أنها فحص بصري ، وتحديد درجة الحموضة ، وقابلية انتشار ، بالإضافة إلى إطلاق عقار في
أشارت النتائج المتحصل عليها إلى أن جميع التراكيز المختلفة لكل بوليمر أعطت نسبة مئوية من
التي تحتوي على البوليكزامر 407 بنسبة F صورة إطلاق الدواء تتناسب عكسي اً مع تركيز البوليمر. أنتجت 8
25 ٪ الافراج عن المخدرات أعلى من الصيغ الأخرى ( 100 ٪ الافراج مع 3 ساعات).
بناء على النتيجة الكلية ، يمكن تحضير البيتاسايتوسترول بنجاح علىشكل هلام مائي موضعي
25 بتركيز ٪ باعتباره أفضل صيغة محضرة.

Preparation and in vitro evaluation of pH sensitive swelling interpenetrating polymer network

a A. Abdul Rassol; Prof. Dr. Ala; Dr. Laith H. Samein; Muqdam M. Mohamad ali

karbala journal of pharmaceutical sciences, Volume 2, Issue 2, Pages 1-14

The semi-interpenetrating polymer network (semi-IPN) is a polymer blend consisting of crosslinked polymer network interpenetrated by linear-chain or branched-chain macromolecule. It was developed to impart promising pH sensitive and swelling properties. The casting method was used to formulate pH sensitive semi-IPN using chitosan and polyvinylpyrrolidone (PVP). The results revealed that the freeze-dried formulas were swelled to very high extent (up to 57.81 folds within 5min) , while the swelling of the air-dried formula didn’t exceed 13.15 folds. Also increasing proportion of PVP from 1.5 to 4.5 relative to chitosan was accompanied by increasing the folds of maximum swelling of network (from 10.90 to 13.15 folds respectively).