ISSN: 7027-2221

Keywords : Heavy Metals


Toxic Effects of Prolonged Ni (II) and Cr (VI) Exposure in Male Mice on Bone Marrow and Some Hematological Parameters

Abeer cheaid yousif AL-fatlawi

karbala journal of pharmaceutical sciences, 2017, Volume 8, Issue 13, Pages 239-248

Heavy metals hazard which can causes toxicological effects on many organs in animals and humans, therefore the purpose of the present study was to investigated the pathological lesion of Nickel (Ni II) and Chrome (Cr VI) metals on some hematological parameters in which heavy metal causes disorder in hematopoietic cell renewal system, which the results showed significant decrease (P≤0.01) in the red blood cells (RBC) count for all doses of Ni and Cr elements, significant decrease (P≤0.05) in the monocytes cell counts only at intermediate and high dose of Ni and Cr elements while significant increase (P≤0.01) of granulocytes cell counts only at high dose for both Ni and Cr elements. Although the results demonstrated there was no any significant difference on platelets for all doses of Ni. On other hand no any significant difference on platelets only at the lowest dose of Cr while, high significant differences (P≤0.01) on platelets at both intermediate and high dose of Cr. Also the results showed significant decrease (P≤0.05) in the bleeding time and clotting time for all groups treated with different doses of both Ni and Cr elements. Dramatic histological lesion for both elements found in the tissue of bone marrow such as degenerate, necrotic and loosely arranged of tissue.

Histopathological changes of heavy metals Nickel Chloride (II) and Potassium dichromate (VI) on the Liver and Kidney of Swiss Male Mice

haider J. Kehiosh; Abeer C.Al-fatlawi

karbala journal of pharmaceutical sciences, 2017, Volume 8, Issue 13, Pages 221-230

Heavy metals are a very harmful environmental pollutant, Nickel and chrome induced toxicity and carcinogenicity, with an emphasis on the generation and role of reactive oxygen species is reviewed. Nickel and chrome are a known as haematotoxic, immunotoxic, neurotoxic, genotoxic, reproductive toxic, pulmonary toxic, nephrotoxic, hepatotoxic and carcinogenic agent. The present study revealed the toxic effects of nickel (Ni) (II) and chrome (Cr) (VI) on the liver and kidney structure of mature male mice weighing 20-30 g, (10-13 weeks old), were treated orally with different doses (20, 40 and 60 mg/kg of NiCl2 and 20, 60 and 100 mg/kg of K2Cr2O7). Dramatic Histopathological changes found in the liver and kidney of treated animals included degeneration, nuclear pycnosis, cellular swelling,necrosis, congestion of blood vessels and many others defects .

Toxic Effects of Prolonged Ni (II) and Cr (VI) Exposure in Male Mice on Bone Marrow and Some Hematological Parameters

Abeer cheaid yousif AL-fatlawi

karbala journal of pharmaceutical sciences, 2017, Volume 8, Issue 12, Pages 99-108

Heavy metals hazard which can causes toxicological effects on many organs in animals and humans, therefore the purpose of the present study was to investigated the pathological lesion of Nickel (Ni II) and Chrome (Cr VI) metals on some hematological parameters in which heavy metal causes disorder in hematopoietic cell renewal system, which the results showed significant decrease (P≤0.01) in the red blood cells (RBC) count for all doses of Ni and Cr elements, significant decrease (P≤0.05) in the monocytes cell counts only at intermediate and high dose of Ni and Cr elements while significant increase (P≤0.01) of granulocytes cell counts only at high dose for both Ni and Cr elements. Although the results demonstrated there was no any significant difference on platelets for all doses of Ni. On other hand no any significant difference on platelets only at the lowest dose of Cr while, high significant differences (P≤0.01) on platelets at both intermediate and high dose of Cr. Also the results showed significant decrease (P≤0.05) in the bleeding time and clotting time for all groups treated with different doses of both Ni and Cr elements. Dramatic histological lesion for both elements found in the tissue of bone marrow such as degenerate, necrotic and loosely arranged of tissue.