ISSN: 7027-2221

Keywords : Nanohybrid


Preparation of Nanohybrid antifungal from Nystatin and determination its inhibitory efficiency against Candida spp.

Zahraa Shakir Mahmod; Ali Abdul Kadhim Al-Ghanimi

karbala journal of pharmaceutical sciences, Volume 6, Issue 9, Pages 145-165

A nanohybrid antifungal Nys-ZnO was prepared using sol-gel ion exchange method between
the antifungal Nystatin (Nys) and Zinc Oxide. The new nanoantifungal was identified. FT-IR
spectroscopy revealed the appearance of new groups in the Nys-ZnO spectrum which indicates the
formation of new compound. The X-Ray Diffraction (XRD) spectrum revealed the appearance of
new diffraction planes in the nanohybrid antifungal spectrum in compare with the spectrum of zinc
oxide. Scanning Electron Microscope (SEM) showed the presence of some change in the Nys-ZnO
surface. The two and three dimensional image of the above compound in atomic force microscope
confirmed the formation of new antifungal with nanodimensions. The antimicrobial activity of the
nanohybrid antifungal was studied against 23 isolates of Candida. Results showed that highest
inhibition was obtained against isolate Candida tropicalis 4 with avarege inhibition zone of 24.08
mm .

Preparation of nanohybrid compound from the food preservative octyl gallate and studying some of its biological activities

Salah Hashim Shaheed; Ali Abdul Kadhim Al-Ghanimi; Abbas Matrood Bashi

karbala journal of pharmaceutical sciences, Volume 5, Issue 7, Pages 277-289

A nanohybrid compound Mg/Al-OG-LDH was prepared using ion exchange method between the food preservative octyl gallate (OG) and Mg/Al layered double hydroxide. The new nanocompound was identified. FT-IR spectroscopy revealed the appearance of new groups in the Mg/Al-OG-LDH spectrum which indicates the formation of new compound. The X-Ray Diffraction (XRD) spectrum revealed the appearance of new diffraction planes in the nanohybrid compound spectrum in compare with the spectrum of layered double hydroxide. Scanning Electron Microscope (SEM) showed the presence of some change in the Mg/Al-OG-LDH surface. The two and three dimensional image of the above compound in atomic force microscope confirmed the formation of new compound with nanodimensions. The antimicrobial activity of the nanohybrid compound was studied against five species of gram positive bacteria. Results showed that highest inhibition was obtained against Staphylococcus aureus with an inhibition zone of 14 mm at 15 mg/ml concentration. The nanocompound was more efficient than the free compound OG in inhibiting the two toxin producers fungi Aspergillus flavus and Aspergillus parasiticus . Results of antioxidants activity showed the ability of the Mg/Al-OG-LDH in scavenging the free radical ATBS where the inhibition percent was at 75 µg/ml.