ISSN: 7027-2221

Keywords : Schiff bases


Synthesis and characterization of new complexes of schiff bases derived from "sulfanilamide" with metal ions Hg+2, Zn+2 and evaluation their biological activity

Rusul.M.Al-kateeb; Safaa A. Al-Samarrai; Malath Kh. Rasheed

karbala journal of pharmaceutical sciences, 2016, Volume 7, Issue 11, Pages 299-313

A new four Schiff bases synthesized by the condensation of the aromatic amine
compound: 4-amino benzenesulfonamide with the four aromatic aldehyde
compounds: 4-chloroBenzaldehyde, 4-BromoBenzaldehyde, 4-HydroxyBenzaldehyde
and 4-(N,N-dimethyl) aminoBenzaldehyde, Also a complexes of pervious ligands were
synthesized with the metal ions with molarity ratio (1:2) M:L. The synthesized
compounds were characterized by physical and spectroscopic measurements (IR
spectrum and proton NMR spectrum, elemental analysis C.H.N, Molar conductivity).
All the synthesized complexes were formed tetra-coordinate complexes and the
supposed chemical formula of the consequent complexes:[M(L)2Cl2]. The Biological
activity were evaluated for the synthesized compounds against two types of bacteria
E.Coli and S.aureus, most of complexes shown anti-bacterial activity.

Preparation and evaluation of the anti-bacterial Activity for some Formazans

Ibtisam K. Jassim; Fawzi H. Jumaa; Omar M. AbdulMuhsin

karbala journal of pharmaceutical sciences, 2015, Volume 6, Issue 10, Pages 0-0

In the present research, a series of Formazans derivatives 7a-j have been prepared by
the condensation of Schiff bases (4,5) and diazonium salt of substituted aromatic amines
Heterocycl, 6a-e. The intermediate Schiff bases (4,5), was itself synthesized by condensation of2-
amino benzothiazole (1), with 4-nitro and dimethylamino benzaldehyde, (2,3). All the reaction
were routinely monitored and purity was determind on thin layer chromatography using coated
aluminum plates and spots were visualized by exposing the dry plates in iodine vapours.The
structures of the compounds have been confirmed by , Mass spectroscopy 1H NMR, U.V, IR
spectral data and melting points. The antibacterial activity of the compounds has also been
screened.

Synthesis and characterization of some new bis 1,3-oxazepines and 1,3-imidazolidine with evaluating of its biological activity.

Fawzi Hameed Jumaa and; Rashed Fadel Abbass

karbala journal of pharmaceutical sciences, 2014, Volume 5, Issue 7, Pages 108-122

In this study some new compounds have been synthesized including preparation of some different Schiff bases (1-5) from the reaction of aromatic amines with terphthadehyde in absolute ethanol and converted into derivatives of 1,3-Oxazepine (of ring closure reaction (2 +5) of Schiff bases with maleic anhydride in benzene (6-10) besides the 1,3- Imidazolidenon (11-15) and evaluation of biological activity for some of them. The prepared compounds were characterized by FT-IR spectra and 1H-NMR spectra for some of the prepared compounds besides the determination of their melting points and TLC (Thin Layer Chromatography.

Synthesis, Characterization and Study Biological activity of some New 1,3-Oxazepine and 1,3-Diazepine derivatives

Ruaa W. Adam; Ezzat.H.Zimam

karbala journal of pharmaceutical sciences, 2014, Volume 5, Issue 7, Pages 195-217

New 1,3-oxazepine and 1,3-diazepine derivatives containing azo group have been prepared. The first step,(O-tolidine) was converted to [3,3`-dimethyl-(1,1`-biphenyl) -4,4`-diyl) bis (diazene-1,2-diyl))bis(naphthalene-2- amine)] Azo O-tolidine[A].by Azotization reaction with naphthyl amine. The second step, amine group of the azo derivative [A] was condensed with different aromatic aldehydes[p-dimethyleaminobenzaldehyde, 4-chlrobenzaldehyde,4-nitrobenzaldehyde,4-bromo benzal dehyde , 4-hydroxy-3-methoxybenzaldehyde] in the presence of absolute ethanol to give new azo Schiff bases derivatives [B-F] respectively. Then, the resulting imines derivatives [B-F] were reacted with maleic anhydride and phathalic anhydride in dry benzene to give new 1,3-oxazepine-4,7-dione ring derivatives [Ba-Fa] , [Bb-Fb] , all these compound reaction with sulphadiazene to producte 1,3-diazepine-4,7-dione ring derivatives [Ba1-Fb2]. Also study the Biological activity to this derivatives ; All prepared compounds were characterized by melting points and FT.IR spectroscopy, some of them are characterized by 1H-NMR spectroscopy and C.H.N analysis.

Synthesis and Biological testing of new 1,3- oxazepine derivatives of pharmaceutical interest

Khalid.M .Mohamad Al-janaby; Ali.I.Mustafa.AL-Jobory

karbala journal of pharmaceutical sciences, 2014, Volume 5, Issue 7, Pages 21-30

Some derivatives of 1,3 oxazepine – Schiff bases have been synthesized by the reaction of some aromatic aldehydes with N-phenyl azo aniline to synthesis of the compounds ,2-(p-phenyl azo)-1,4-phenylene aniline(1-6) ,and these compounds (1-6) were reacted with phthalic anhydride to obtain derivatives of 1,3- oxazapine. The chemical structures of the products were characterized by (IR ,and 1H NMR) and biological activity for some of these compounds were studied against three kinds of bacteria

Synthesis , Characterization and antibacterial activity of Several New Schiff Bases Linked to Phthalimide Moiety

Marwa Shawqi Abdul Razzak; Ahlam Marouf Al-Azzawi

karbala journal of pharmaceutical sciences, 2011, Volume 2, Issue 2, Pages 124-133

Some novel Schiff bases linked to phthalimide moiety have been synthesized via multistep synthesis. The first step involved reaction of phthalic anhydride with aniline producing N-phenyl phthalamic acid which was subsequently dehydrated to the corresponding N-phenyl phthalimide via treatment with acetic anhydride and anhydrous sodium acetate. The synthesized imide was treated with chlorosulfonic acid in the third step producing 4-(N-phthalimidyl)phenyl sulfonyl chloride which on amination with hydrazine hydrate in the fourth step afforded 4-(N-phthalimidyl)phenyl sulfonyl hydrazine and this in turn when introduced in condensation reaction with various aromatic aldehydes and ketones afforded the desirable new Schiff bases.
Structures of the prepared compounds were elucidated on the basis of FTIR, 1HNMR and 13CNMR spectral data which agreed with the proposed structures.
The synthesized compounds were screened for their antibacterial activity against two microorganisms Staphylococcus aureus and Escherichia Coli and they were found to exhibit good to moderate antibacterial activity.