ISSN: 7027-2221

Keywords : Triazole

Synthesis of Some 1 ,3 ,4- Oxadiazole and 1,2,4-Triazole Derivatives and Evaluation the Antibacterial Activity

Gazwan H. Al-Somaidaie; Fawzi H. Al-Obaidy; Shaymaa H. AL-Jebory

karbala journal of pharmaceutical sciences, Volume 3, Issue 3, Pages 152-166

Some of hydrazone derivatives[2a-e] were prepared from the reaction of 2-phenyl acetic acid hydrazide[1] with different substituted benzaldehydes, then cyclization of hydrazones in glacial acetic acid and lead dioxide resulted into the formation of new 1,3,4-Oxadiazole derivatives [3a-e], Symmetrical 4-amino Triazole derivatives [5a-e] were prepared from reaction of 3,5-dibenzyl-4-amino 1,2,4-Triazole[4] with different substituted benzaldehydes to product new series of different Schiff bases [5a-e]. The prepared compounds were characterized by FT-IR, and UV spectroscopy, the melting points were determined and the purity and reaction time was checked by TLC, the biological activity was evaluated against different types of bacteria.

Synthesis and characterization of some substituted heterocyclic compounds and evaluation of biological activity

Wissam K.Jassim; Amina A. Fayad; Ibtisam K.Jassim

karbala journal of pharmaceutical sciences, Volume 2, Issue 2, Pages 228-240

This work includes preparing of some new derivatives of 1,2,4-Triazoles and oxazoles from the reaction between 3,5-dimethyl phenol and chloroethyl acetate in the presence of potassium carbonate and dry acetone to obtain the ester ethyl 3,5-dimethyl phenoxy acetate , then converted this ester to Thiosemicarbazone and Semicarbazone. Then ,the Triazoles were prepared from the cyclization of these Thiosemcarbazones and Semicarbazones in alkaline media( potassium hydroxide solution) . The prepared compounds were characterized by spectral methods FT-IR ,1H-NMR and measurement of some of its physical properties and evaluation of the biological activity for some of them.