ISSN: 7027-2221

Keywords : Atorvastatin

Obesity And Inflammation Induces By High Fat Diet Concomitant With Mild Fatty Streak In Coronary Artery: Immuno-Histopathological Study

Jasem Hannon Hashim Al-Awadi; Alaa Jawad Hassen; Karem Hammed Rashid

karbala journal of pharmaceutical sciences, Volume 4, Issue 6, Pages 9-20

This research was designed to study the obesity which induced by rats fed on high fat diet which characterized by gain in body weight and elevation of some immunological parameters which often concomitant with mild to moderate fatty streak in coronary artery and the effects of atorvastatin treatment of male albino rats, the result showed:
High significant increase(p<0.0005)in total and gain body weight of positive control rats, while atorvastatin treatment caused significant decrease(p<0.005) in both total and gain body weight of hyperlipidemic rats as compared with positive control group, also atorvastatin reduce gain body weight in normolipidemic rats as compared with negative control group.
There were high significant increase(p<0.0005)in C3,C4 in normolipidemic rats which treated with atorvastatin, while there were significant increase(p<0.0005)in CRP,C3,C4 in hyperlipidemic rats of positive control group, whereas the treatment by atorvastatin result in returned the concentration of CRP,C3,C4 to its normal values as compared to negative control rats.
The histological sections of coronary arteries and its some branches were revealed the presence of fatty streak, infiltration of fat laden cells(foam cells)in subintimal layer of coronary arteries of positive control rats ted on HFD,also smooth muscle cell proliferation, vacuolar of tunica media were observed in the coronary arteries of these animals as a signs of onset of atherosclerosis, whereas atorvastatin reduced completely the presence of all these changes after three months of treatment.Thus our conclusions that atorvastatin reduced the body weight gain in hyperlipidemic animals, induce inflammatory changes in normolipidemic animals and reduced all signs of atherosclerosis in coronary arteries.

High Fat Diet Induce Hyperlipidemia Incidences With Sever Changes in Liver Tissue of Male Albino Rats: A Histological and Biochemical Study

Jasem Hannon Hashim Al-Awadi; Karem Hammed Rashid; Alaa Jawad Hassen

karbala journal of pharmaceutical sciences, Volume 4, Issue 6, Pages 21-32

This study was designed to investigate the effects of high fat diet on liver tissue as well as biochemical changes of lipid profiles of hyperlipidemic and normolipidemic rats which treated with atorvastatin before and after induction of hyperlipidemia by feeding the rats with high fat diet, the result showed:
There was high significant increase(p<0.0005)in TC,TG,LDL,VLDL , and AI, but there was high significant decrease in HDL in rats fed on HFD for seven months if compared with negative control group, while atorvastatin treatment caused high significant decrease(p<0.0005)in lipid profile parameters after three months of treatments if compared to positive control group. Atorvastatin treatment result in high significant decrease (p<0.0005,p<0.005)in TC,TG,LDL,VLDL, and AI in normolipidemic rats as compared with negative control group.
The histological sections of liver were revealed presence of severe histopathological changes which classified into grades between 0-4. The most severe changes were in liver sections of hyperlipidemic rats which consist: infiltration of lipids in micro, mid, and macro vascular steatosis, while some livers were observed to contain onset of fat sacs, damage of unique radial appearances of hepatocytes in hepatic lobule, lymphocytes infiltration, congestion also observed in some liver section of these animals, whereas the histopathological changes in livers of normolipidemic rats which treated with atorvastatin were less severity as compared with positive control rats these changes included: sever lymphocytes infiltration especially around central portal vein, pyknotic nuclei, severe congestion and loss radial appearances of hepatocytes also there was dilatation of central portal vein and some bile ducts, while atorvastatin treatment reduce the effects mentioned in some hyperlipidemic individuals.