ISSN: 7027-2221

Keywords : seven heterocyclic rings

Synthesis and Identification of some 1,3-oxazepine derivatives containing p-methoxy phenyl and studying their anti bacterial activity

Bushra A.Kherallah

karbala journal of pharmaceutical sciences, 2014, Volume 5, Issue 7, Pages 31-41

This search includes preparation p-methoxy benzoyl hydrazine (II2) from the reaction between p-methoxy ethyl benzoate (I1) with hydrazine haydrate with the existence of ethanol absolute , then they were converted to hydrazine derivatives with different substituents (III3-6) through the reaction with aromatic benzaldehyde with out using a solvent under thermal fussion . Compounds of 1,3-oxazepine-4,7-dione (IV7-10) have also been prepared by ring closer reaction through the treatment of the prepared hydrazones (III3-6) and maleic anhydride ,The structure of the synthesis compounds was confirmed by FT-IR and 1HNMR spectral data , as the physical means ,the biological activity was studied againt two types of bacteria.