ISSN: 7027-2221

Keywords : Micro sponges


Formulation and evaluation of clarithromycim oral microspong

Jenan m. Mohsin al mosawi; laith hamza samein; alaa abdul- razzaq

karbala journal of pharmaceutical sciences, Volume 6, Issue 9, Pages 114-123

Clarithromycin is a broad-spectrum antibiotic and extensively absorbed orally. It is be used in the
eradication of H. Pylori infection combined with an acid suppressing agent. The purpose of this study
was to develop controlled release clarithromycin floating micro sponges for gastro retentive drug
delivery. The micro sponge’s formulations were prepared by quasi-emulsion solvent diffusion
method employing eudragit RS 100 as a polymer and poly vinyl alcohol (PVA) as a surfactant.
The compatibility of the drug with formulation components was established by Fourier
Transform Infra-Red (FTIR) spectroscopy. The prepared microsponge were evaluated for angle
of repose, Carr's Index ,particle size, floating time production yield, drug loading efficiency of
micro sponges. Shape and surface morphology of the micro sponges were been examined using
scanning electron microscopy. formulation F5 with drug to polymer ratio 8:1,10 ml of internal
phase volume (ethanol: dichloromethane) and 0.25%pva solution was the best formula
showing the highest degree of sustained release that is 79.59% at the end of 12 hours with
floating time for 12 hr. Eudragit RS 100 could control drug release in stomach.