ISSN: 7027-2221

Keywords : oxazepine

Synthesis and Identification of some 1,3-oxazepine derivatives containing p-methoxy phenyl and studying their anti bacterial activity

Bushra A.Kherallah

karbala journal of pharmaceutical sciences, 2014, Volume 5, Issue 7, Pages 31-41

This search includes preparation p-methoxy benzoyl hydrazine (II2) from the reaction between p-methoxy ethyl benzoate (I1) with hydrazine haydrate with the existence of ethanol absolute , then they were converted to hydrazine derivatives with different substituents (III3-6) through the reaction with aromatic benzaldehyde with out using a solvent under thermal fussion . Compounds of 1,3-oxazepine-4,7-dione (IV7-10) have also been prepared by ring closer reaction through the treatment of the prepared hydrazones (III3-6) and maleic anhydride ,The structure of the synthesis compounds was confirmed by FT-IR and 1HNMR spectral data , as the physical means ,the biological activity was studied againt two types of bacteria.

Synthesis and Biological testing of new 1,3- oxazepine derivatives of pharmaceutical interest

Khalid.M .Mohamad Al-janaby; Ali.I.Mustafa.AL-Jobory

karbala journal of pharmaceutical sciences, 2014, Volume 5, Issue 7, Pages 21-30

Some derivatives of 1,3 oxazepine – Schiff bases have been synthesized by the reaction of some aromatic aldehydes with N-phenyl azo aniline to synthesis of the compounds ,2-(p-phenyl azo)-1,4-phenylene aniline(1-6) ,and these compounds (1-6) were reacted with phthalic anhydride to obtain derivatives of 1,3- oxazapine. The chemical structures of the products were characterized by (IR ,and 1H NMR) and biological activity for some of these compounds were studied against three kinds of bacteria

Synthesis and Chemico-Biological Studying of Various Organic Compounds

Nagham Mahmood Aljamali; Hameeda Eedan Salman

karbala journal of pharmaceutical sciences, 2013, Volume 4, Issue 4, Pages 73-84

In this work ,synthesis of variety of organic compounds [1-6] such as thiol compound , oxazepine (oxazepam) ,diazepine (diazepam) ,macrocyclic Schiff base ,azo compound which contains electron donating group and azo compound is containing electron with drawing group and identification of their structures by {(C.H.N) microanalysis , 1H-NMR spectra and (FT-IR) – spectrum } and study of their biological activities , the data obtained give good supported for synthesized compounds[1-6]

Synthesis ,characterization and investigation of biological activity of new heterocyclic compounds

Ibtisam K.Jassim

karbala journal of pharmaceutical sciences, 2011, Volume 2, Issue 2, Pages 196-217

A new compounds of 2-amino-5-(m-nitro phenyl)-1,3,4-oxadiazole [1] and 2-amino -5- phenyl-1,3,4-oxadiazole[2], N[(o-hydroxy benzylidene-5-( phenyl-2-yl)-1,3,4-oxadiazole-2-amine][3] or N[(m-nitro benzylidene-5-(m-nitro phenyl-2-yl)-1,3,4-oxadiazole-2-amine][4], 2-(m-nitro phenyl) -3 (5-m-nitrophenyl)1,3,4-oxadiazole]-2-yl-thiazolidin-4-one [5], 2-(m-nitro phenyl) –tetrazolo-1-yl)- 5-(m-nitrophenyl )1,3,4-oxadiazole ] [6] , 5-(m-nitro phenyl)-2/-(m-nitrophenyl)-2-yl-2,3-dihydro-1,3-oxazpine-4,7-dione [7] , 4-hydrazino nicotinic acid [8], 1-phenyl-4-(nicotinoyl) thiosemicarbazide [9], and 3-hydrazino-5- (pyridyl )-1,2,4- Triazole-4-phenyl [11], 3-(p-N,N/ dimethyl amino benzylidene)- hydrazino -5- (pyridyl )-1,2,4- Triazole-4-phenyl [12], 4-(3-methyl pyrazol-5-one)- hydrazino -5- (pyridyl )-1,2,4- Triazole-4-phenyl [13], 4-(3,5-dimethyl pyrazol)- hydrazine-5- (pyridyl )-1,2,4- Triazole-4-phenyl [14], ethyl 4-bromo-phenoxy acetate [15], p-bromo pheno -aceto thiosemicabazone [16] ,2- amino-5-[(p-bromp phenoxymethylene)-1,3,4-thiadiazole [17], 2N( p-nitro benzylidene)-1,3,4-Thiadiazole -5- (p-bromo phenoxy methyl [1 8 ], 5 -(p-bromo phenoxy methyl) 2/-(p-nitro phenyl- 2-yl)-5,6-dimethyl-1,3-oxazpine-4,7-dione [19] or5-(p-bromo phenoxy methyl) 3-(p-nitro phenyl- 2-yl)-2,3-dihydro-1,3-oxazpine-4,7-dione [20] and imidazoline[21].
The chemical structures of these compounds were identified by FT-IR,H-NMR , Uv spectroscopy and the reaction time ,purity was checked by TLC with determining the melting points. Some of the new compounds were tested against four strains of bacteria ( Klebsiella Pneumoniae ,Pseudomonas aeuroginosa ,Staphylococcus Aureus and Bacillus subtilus ) comparing these activities with that of starting material