ISSN: 7027-2221

Keywords : Type

Association Between Total antioxidant Capacity and Leptin Levels in Type-2 Diabetic Patients

Dr.Riyadh Al-Zubaidi; Dr.MohammedT.Abbas

karbala journal of pharmaceutical sciences, Volume 8, Issue 12, Pages 29-33

Diabetes is a long life condition that causes a person's blood sugar level to become too high. Type 2 diabetes occurs when the body doesn't produce enough insulin to function properly, or the body’s cells don't react to insulin. This means that glucose stays in the blood and isn't used as fuel for energy. The present study was conducted to investigate the serum total antioxidant capacity ,serum leptin ,blood glucose and lipid profile and its association with the type 2 diabetes mellitus. The study was case control conducted 55 male with Type II diabetes and 17 male volunteers were healthy control group, blood samples collected after 14 h fasting Parameters was measured with special enzymatic kits. The present study show significant decline of serum total antioxidant capacity among diabetic cases compared with control group (p< 0.001), serum lepton was and blood glucose significantly high in type 2 diabetes patients group compared with control group (P < 0.001) . Serum cholesterol, LDL-C and triglyceride were high but no significant in type 2diabetes patients group than normal control group (P < 0.001),while serum HDL-C level was lower non-significant in type 2diabetes patients than control group. We concluded the wasSignificant decline in serum total antioxidant and significant elevations in serum leptin intype2 diabetes in comparison with normal subjects.

Is There Any Association Between Type 2 Diabetes Mellitus and Biochemical Evidence of Vitamin D Deficiency?

Riyadh Mustafa Murtadha

karbala journal of pharmaceutical sciences, Volume 4, Issue 6, Pages 147-152

Background: Type 2 Diabetes Mellitus is a major public health problem, known to be multifactorial in origin. Over the last years, a number of observational studies have suggested an association between type 2 diabetes mellitus and vitamin D deficiency.
Objective: To identify any association between type 2 diabetes mellitus and biochemical evidence of vitamin D deficiency in our population.
Methods: This study was conducted at outpatient clinic in Karbala throughout the year 2011, with a cross-sectional design. The populations were patients with type 2 diabetes mellitus and non-diabetic subjects, who visited the clinic for treatment; all of them had normal renal function. Data collected including characteristics, such as age, sex & body mass index; and the laboratory data such as serum level of calcium, phosphorus, albumin and alkaline phosphatase. Statistical analysis was done by using Chi-Square test and multivariate analysis.
Results: A total number of 64 subjects (Age 45-75 years; 67% female); of them, 32 subjects with Type 2 diabetes mellitus, and 32 subjects without diabetes mellitus. The biochemical evidence of vitamin D deficiency was found in 22% (7 out of 32) of diabetic patients, while it was in 25% (8 out of 32) of non-diabetic subjects. So, there was no statistical difference between the two groups. Moreover, among diabetics, there was no effect of vitamin D deficiency on blood sugar control by measuring HbA1C level.
Conclusions: The association between type 2 diabetes mellitus and biochemical evidence of vitamin D deficiency cannot be proven statistically in this study.

Purification of (AST) From Sera of Type П Diabetic Patients

Sayran Sattar Saleh

karbala journal of pharmaceutical sciences, Volume 2, Issue 2, Pages 35-41

This study was performed on (35) serum specimen of patients having type 2 diabetes in addition , (40) normal specimens were investigated as control group . The activity of (AST) in diabetic patients was reached to (75.2 ± 11.7) IU/L as compared with normals (19.9 ± 6.1) IU/L . Purification of (AST) from sera of diabetic patients was performed by dialysis and gel filteration (Sephadex G 25) the results of study reveal that Aspartate aminotransferase (AST) activity of type 2 diabetes patient's serum show ahigh significant increase (p< 0.001) compare to normal subject.