ISSN: 7027-2221

Keywords : VCAM

A study of sICAM-1,sVCAM-1 and sE-Selectin Profile in type II diabetes and latent autoimmune diabetes of adult.

Sawsan M Jabbar Al-Hasnawi; Alaa Saad Al-Attabi; Zainab Abdu Al Ruda

karbala journal of pharmaceutical sciences, Volume 7, Issue 11, Pages 256-269

Intercellular adhesion molecule 1( ICAM-1) and vascular cell adhesion molecule
VCAM-1 are members of the immunoglobulin superfamily bind to other
members of the superfamily, to integrins or to a diverse range of additional
counter-receptors. E-selectin which is presented on endothelial cells when its
activated acutely. Serum levels of adhesion molecules like ICAM-1 measurement
are possible after shedding of these molecules from active surface of endothelial
cells and macrophages in diabetes patients following hyperglycemia as in patient
with LADA and type II diabetes mellitus .So that this study was done for
measuring serum level of ICAM-1,VCAM-1 and E-Selectin Profile in type II
diabetes and latent autoimmune diabetes of adult and study their relation with
level of HbA1C , gender , age ,BMI and complication of diabetes. In the study the
serum of 36 patients with type2 diabetes mellitus ,34 patients with LADA and
20 healthy subjects test by ELISA technique for measuring the level of ICAM-
1,VCAM-1 and E-selectin . The study resulted in the mean sVCAM-1level of
control group was significantly lower than D.M.2 and LADA group, P<0.05. The
sE- Selectin level was higher in LADA group than control and D.M. type 2
group & significantly different when compared to control group (P<0.05). The
sVCAM-1 level had a significant positive correlation (R=0.25, P=0.017) with
BMI in all groups. High level of (sICAM-1,sVCAM-1 and sE-Selectin ) are
associated with increased incidence of complication .

Intercellular adhesion molecules -1 (ICAM-1) and Vascular cell adhesion molecules-1 (VCAM-1) in hypertensive patients suffering from bacterial UTIs .

Nidhal abdul Mohaimen; Arif Sami; Zainab Thamer Showait Al-assady

karbala journal of pharmaceutical sciences, Volume 4, Issue 5, Pages 56-68

Leukocyte binding to cellular adhesion molecules (CAMs) on the surface of vascular endothelial cells appears to be one of the earliest events in the atherosclerotic process. In this study the concentration of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on lymphocytes were evaluated during vascular disease like hypertension . In addition level of CAMs in hypertensive patients in response to other factors like sex, aging , smoking , anti hypertension drugs treatment (mainly with some β-blockers(propranolol) or ACE inhibitors(captopril)) and UTIs were also measured . As compared to controls mean of ICAM-1 and VCAM-1 were significantly elevated in hypertensive subjects. VCAM-1 was significant in male compared to female . Significant positive correlation was observed of VCAM-1 level in relation to ageing , Smoking and in hypertensive patients suffering from UTIs. While the level of both ICAM-1 and VCAM-1 was found to be decreased upon anti hypertension treatment with either β-blocker or ACE inhibitor decreased.