ISSN: 7027-2221

Keywords : Ellagic acid

Isolation, Characterization and Estimation of Ellagic Acid activity against Porphyromonas gingivalis Isolated from adult Periodontitis Patients in Kerbala City.

Alnasrawy; A.A; Y.A; Al-Khafaji; Altmimy; F.M; Alnasrawy; M.S

karbala journal of pharmaceutical sciences, 2015, Volume 6, Issue 9, Pages 16-29

Periodontitis is a chronic bacterial infection affects the gingiva, periodontium connective
tissues and alveolar bone, results in alveolar bone resorption, ultimately, partially or
completely tooth loss, indeed, it may causes various serious systemic complications like
Diabetes Mellitus, Cardiovascular disorders, Rheumatoid Arthritis, Preeclampsia with low
birth weight and Orodigestive cancer mortality. Porphyromonas gingivalis is considered the
main, foremost and strongest periodontal pathogen. Isolation, characterization and monoplex
PCR of 16S rRNA and multiplex PCR of fimA geneotyping are the golden standard assays for
detection of P.gingivalis in adult periodontitis patients. In the present study,Pomegranate peel
Ethanol extract partially purified ellagic acid has an obvious effectiveness against oral
pathogens (P. gingivalis and S. mutans) in both growth inhibition zone on solid medium and
Percentage of growth reduction in a liquid medium in various concentrations with common
MIC 16mg/ml.