ISSN: 7027-2221

Keywords : Nanoparticles


Erectile Dysfunction in Diabetic Patients in the Holy Kerbala/Iraq in 2018

karbala journal of pharmaceutical sciences, Volume 9, Issue 15, Pages 1-10

Background
Erectile dysfunction affects more than 50% of diabetic patients and results in miserable
couple’s life, especially for young adults. Possible predictors are proper therapy and
patient’s compliance with treatment, in addition to the warning signs and symptoms of
sensory neuron and motor deficits. Therefore, this study was conducted to determine the
prevalence of Erectile dysfunction and its predictors among diabetic patients in Kerbala.
Material and methods
The study included a convenient sample of 61 patients with diabetes mellitus type I and II.
They were chosen through a systematic sampling among patients at the diabetes mellitus
clinic at Al Hussein Teaching Hospital in Holy Kerbala /Iraq in 2018. All participants
were interviewed using standard questionnaire. Analysis of data used descriptive and
analytic tools including t-test, chi-square test, logistic regression and structural Equation
modeling through the statistical Package of social sciences and Amos and Excel software
at a significance level of

Keywords

diabetes mellitus
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erectile dysfunction
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Autonomic changes
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sensory and motor changes
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glycemic control.

Effects of formulation variables on the Candesartan cilexitil nanoparticles properties using polyvinyl pyrroledone

karbala journal of pharmaceutical sciences, Volume 9, Issue 15, Pages 63-72

Candesartan celexitil (CC), a non-peptide angiotensin II type 1 (AT1) receptor
antagonist, is used in the treatment of hypertension. It has low solubility with low
bioavailability thus nanoparticles approach is one of the recently technique used to
enhance the solubility of drugs. The aim of this study is to improve the solubility of CC
by preparing nanoparticles. Seven formulas of nanoparticles were prepared by antisolvent
precipitation method utilizing polyvinylpyrrolidone (PVP) as polymer. Three formulas
were prepared at different drugs: polymer ratio and another three formulas were at
different solvent: anti solvent ratios. The prepared nanoparticles were characterized
regarding the particle size by nano laser particle size analyzer, saturated solubility, and
thermal analysis by differential scanning calorimetry (DSC). The prepared nanoparticles
reveal that all formulas produce nanoparticle in range of (50 – 706) nm. Formula (F2)
which utilizes (PVP) as polymer at polymer: drug ratio of (1:1) and solvent: anti solvent
ratio of (1:10) was considered as the best formula which shows good evaluation
parameters in addition to increment in solubility (10.54) times than that of pure drug. The
thermal analysis of nanoparticle of the selected formula (F2) shows reducing of intensity
of endothermic peak of the drug indicating reduced crystallinity of candesartan celexitil.
Finally, it could be concluded that the selected formula is promising for preparation of
candesartan cilexetil nanoparticles with improved solubility.كانديسارتان سيليكسيتيل هو عقار غير مثبط غير ببتيدي لمستقبلات الانجيوتنسينوجين الثاني من النوع الأول يستخدم في علاج
ارتفاع ضغط الدم العقار له قابلية ذوبان منخفضة في الماء مع انخفاض التوافر البايولجي وبالتالي تقنية النانونوتكنولوجي هي
واحدة من التقنيات في الآونة الأخيرة التي تستخدم لزيادة ذوبان الأدوية . والهدف من هذه الدراسة هو تحسين ذوبان
الكانديسارتان سليكسيتيل من خلال إعداده على شكل جسيمات نانويه . وقد أعدت سبعة صيغ من الجسيمات النانوية بطريقة
الترسيب بمضاد المذيب واستخدام بولي فنيل بايروليدون على صيغ مختلفة من نسب الدواء إلى البوليمر ونسبة المذيب إلى
المضاد للمذيب . وقد تم تقييم الجسيمات النانوية المحضرة بشان حجم الجسيمات باستخدام جهاز النانو الليزري المحلل للجسيمات , ودرجة الذوبان, والتحليل الحراري باستخدام .النتائج أظهرت أن كل الصيغ أنتجت جسيمات متناهية الصغر في
2) فيها نسبة البوليمر إلى الدواء هو ( 1:1 ) ونسبة المذيب إلى مضاد المذيب F) 709 ) نانو متر.واعتبرت الصيغة - قيم من ( 50
هي ( 1:10 ) باعتبارها أفضل صيغة مع مواصفات جيدة بالإضافة إلى زيادة في الذوبان ( 10.5 ) مرات مقارنة بالدواء
2) إلى قلة في شدة ذروة إشارة الدواء في F) النقي.ويظهر التحليل الحراري للجسيمات المتناهية الصغر من الصيغة المختارة
التحليل مشيرا إلى انخفاض التبلور في الدواء . وأخيرا يمكن القول إن الصيغة المختارة واعدة لإعداد الصيغة النانوية
الكانديسارتان سيليكسيتيل مع تحسن واضح بالذوبان .

Preparation and Evaluation of Dapsone Nanoparticles

Ahmed Najim Abood; Yasamin Abdulhadi Sallal

karbala journal of pharmaceutical sciences, Volume 8, Issue 13, Pages 320-335

Objective: Preparation of Dapsone nanoparticles to get optimized solubility, rate of dissolution and then more bioavailability.
Methods: Dapsone nanoparticles were prepared using solvent-antisolvent precipitation method. A Certain amount of drug was dissolved in water-miscible solvent (ethanol or methanol), then this solution was injected at certain speed (ml/min.) into water containing stabilizer. Upon injection, precipitation of Dapsone nanoparticles will occur immediately accompanied with stirring for 30 min. at 50˚C, and then the selective formula is lyophilized. Different formulas of Dapsone nanoparticles were prepared at different polymer types, drug: polymer ratios and different organic solvent types. Characterization of these formulas involve measurement of particle size, particle morphology, saturation solubility, release profile, crystallinity, physical and chemical compatibilities between the drug and involved stabilizers.
Results: Results show that the best formula of nanoparticle (F3) prepared by dissolving 16.6 mg/ml of Dapsone in ethanol, then 3ml was injected into to a 25 ml of water with PVP (polyvinyl pyrrolidone) as a stabilizer at ratio 1:4 (drug: stabilizer) then lyophilized to obtain nanoparticles. The best formula characterized by particle size around 28.5 nm, poly-dispersity (= 0.009), specific surface area (= 78.18), without physical or chemical incompatibility, and the dissolution rate was significantly higher than that of the raw Dapsone powder.

Effects of formulation variables on the Candesartan cilexitil nanoparticles properties using poloxamer 188

Alaa Mohamed Baqer; Mowafaq Mohammed Ghareeb; Muder AL Haydar

karbala journal of pharmaceutical sciences, Volume 6, Issue 9, Pages 105-113

Candesartan celexitil (CC), a non-peptide angiotensin II type 1 (AT1) receptor antagonist, is
used in the treatment of hypertension. It has low solubility with low bioavailability thus
nanoparticles approach is one of the recently technique used to enhance the solubility of
drugs. The aim of this study is to improve the solubility of CC by preparing nanoparticles.
Seven formulas of nanoparticles were prepared by antisolvent precipitation method utilizing
poloxamer 188 as polymer. Three of them at different drugs: polymer ratio and another three
different solvent: anti solvent ratios. The prepared nanoparticles were characterized regarding
the particle size by nano laser particle size analyzer, saturated solubility, and thermal analysis
by DSC. The prepared nanoparticle reveals that all formulas produce nanoparticle in range of
70.6 - 1119 nm. Formula (F2) which utilizes PXM as polymer at polymer: drug ratio of (1:1)
and solvent: antisolvent ratio of (1:10) was considered as the best formula which shows good
evaluation parameters in addition to increment in solubility 10.54 times than that of pure
drug. The thermal analysis of nanoparticle of the selected formula (F2) shows reducing of
intensity of endothermic peak of the drug indicating reduced crystallinity of candesartan
cilexetil. Finally it could be concluded that the selected formula is promising for preparation
of candesartan cilexetil nanoparticles with improved solubility.