ISSN: 7027-2221

Author : A. Fayad, Amina

Synthesis and characterization of some substituted heterocyclic compounds and evaluation of biological activity

Wissam K.Jassim; Amina A. Fayad; Ibtisam K.Jassim

karbala journal of pharmaceutical sciences, Volume 2, Issue 2, Pages 228-240

This work includes preparing of some new derivatives of 1,2,4-Triazoles and oxazoles from the reaction between 3,5-dimethyl phenol and chloroethyl acetate in the presence of potassium carbonate and dry acetone to obtain the ester ethyl 3,5-dimethyl phenoxy acetate , then converted this ester to Thiosemicarbazone and Semicarbazone. Then ,the Triazoles were prepared from the cyclization of these Thiosemcarbazones and Semicarbazones in alkaline media( potassium hydroxide solution) . The prepared compounds were characterized by spectral methods FT-IR ,1H-NMR and measurement of some of its physical properties and evaluation of the biological activity for some of them.