Author : J. Al-Tu, Fadhil
karbala journal of pharmaceutical sciences,
Volume 2, Issue 2, Pages 157-166
Background: The association between obesity and type-2 diabetes mellitus may be partly mediated by altered secretion of adipokines by adipose tissue. Adiponectin is an adipokines with anti-inflammatory and insulin sensitizing properties; it is secretion is down regulated in obesity. The correlation of plasma adiponectin with the risk of type-2 diabetes mellitus and hyperlipidemia is unclear.
Objective: To study the association between plasma adiponectin level with lipid profile in type-2 diabetic obese patients in Kerbala province: Iraq.
Material and method: A total number of 110 sample subjects with different age, and different gender were classified according to diabetes mellitus and obesity. Fasting serum adiponectin was measured by ELISA method. Measurements of fasting lipid profile also have been performed.
Results and discussion: It was obtained that adiponectin level was lowered significantly in diabetic group, obese group, and diabetic obese group as compared with control group. Serum adiponectin was correlate negatively with serum total cholesterol, serum TG, and with body fat percent (BF %), while it was correlated positively with HDL-C. Serum total cholesterol levels was correlated positively with each of serum TG, LDL-C levels and with BF%, while serum TG levels was negatively correlated with serum HDL-C and positively correlated with each of BMI and BF %. Serum LDL-C was positively correlated with BF %, while BF % correlates positively with age.
Conclusion: According to the presented data, adiponectin as hormone play an important role in the prevention of hyperlipidemia, and consequently atherosclerosis and its complications.