karbala journal of pharmaceutical sciences

Reaction of different substi tuents of 2-azobenzothiazolyl 4-phenols (I) with ethyl 2-bromo propionate to produce the derivatives (II) that react with thiosemicarbazide gave N-substituted thiosemicarbazide (III) also react with semicarbazide and which gave N-substituted semicarbazide (IV). The 1,2,4-triazole derivatives (V) and 1,3,4- thiadiazole derivatives (VI) were prepared by the cyclization of N-substituted thiosemicarbazide (III) with base and with concentrated sulphuric acid respectively . The 1,3,4-oxadiazole derivatives (VII) were prepared by the cyclization of N-substituted semicarbazide (IV) with acid. the new compounds were established on the basis of IR, 1H NMR and UV spectral data.