Author : Kadhum Yaseen, Hiba
Synthesis and Priliminary Evaluation of Antibacterial Activity of a Series of New Phthalimides and Succinimides Linked to Benzothiazole Moiety
karbala journal of pharmaceutical sciences,
Volume 3, Issue 3, Pages 260-275
A series of new phthalimides and succinimides linked to benzothiazole moiety were synthesized and followed by their antibacterial screenings. Synthesis of the new imides was performed via two steps, the first one involved preparation of a series of N-(substituted benzothiazole-2-yl) phthalamic and succinamic acids via reaction of phthalic anhydride or succinic anhydride with substituted-2-aminobenzothiazoles.
In the secound step the prepared phthalamic and succinamic acids were dehydrated via treatment with acetic anhydride and anhydrous sodium acetate to afford a series of the desirable N-(substituted benzothiazole-2-yl)phthalimides and succinimides. Structures of the prepared compounds were confirmed by spectroscopic methods including FTIR, U.V., 1H-NMR, 13C-NMR spectroscopy and C.H.N analysis.
The synthesized imides were screened for their antibacterial activity against two types of bacteria Staphylococcus aureus and Eschrichia coli. The new compounds were found to exhibit good to moderate antibacterial activity.