ISSN: 7027-2221

Author : K.Jassim, Ibtisam

Synthesis and characterization of new heterocyclic compounds with studying its biological activity

Hilal.M.Abdullah; Ibtisam K.Jassim; Malak N.Safi

karbala journal of pharmaceutical sciences, Volume 4, Issue 4, Pages 119-135

Reaction of malonic acid di hydrazide (1) with CS2 / KOH then with hydrazine hydrate gave 1,2,4-triazole (2) which was reacted with different substituted benzaldehyde to give Schiff bases derivatives (3-8) respectively. Schiff bases (3-8) were reacted with thioglycolic acid to give thiazolidenones (9-13). Also ,Schiff bases were reacted with glycine to give imidazolidenone (14-18). The prepared compounds were characterized by FT-IR ,1H-NMR ,Uv/vis spectra ,melting points were recorded and the purity was checked through T.L.C.technique. Some of the synthesized compounds were screened for antibacterial activity