Author : Rahman Ahmad, Nief
Spectrophotometric determination of clioquinol via complex formation with Fe( III )in pharmaceutical preparations (creams) and environmental wastewater samples
karbala journal of pharmaceutical sciences,
Volume 4, Issue 5, Pages 91-99
To develop spectrophotometric method for the determination of clioquinol in pharmaceutical preparations and industrial wastewater samples. The method is based on the chelating of the drug with Fe( III) to form blue- green colored metal - chelate at room temperature which absorbs maximally at 639 nm. Beer' s law is obeyed over the concentration range of 2.00-20.00 µg/ml (6.5x10-6 - 6.5x10-5 M) with molar absorptivity and Sandell'҆ s sensitivity of 0.611x104 l/mol.cm and 5x10-5 mg/cm respectively, relative standard deviation (RSD) is less than 2.00% (n=10.00). The method is applied successfully for determination of clioquinol in some pharmaceutical formulations (creams) and industrial wastewater samples.