ISSN: 7027-2221

Author : Hamid Ouda, Mazin

Hepatoprotective effect of green tea (Camellia sinensis) on female rats drenched with paracetamol

Shatha hussein kadhim; Amal Umran Mosa; Mazin Hamid Ouda

karbala journal of pharmaceutical sciences, Volume 4, Issue 6, Pages 110-116

Hepatotoxicity is an acute adverse effect of paracetamol overdose which could be fatal, so in this research we studied the effect of paracetamol on liver enzymes (GPT, GOT, total protein , glucose ,uric acid ) of female rats that drenched green tea. twenty laboratory female rats housed in plastic cages in animal house at Karbala university/ college of pharmacy , the animals divided randomly into five groups ,(G1 control, G2 drenched with 300 mg/kg green tea and 500 mg/kg paracetamol, G3 drenched with 500 mg/kg green tea and 500 mg/kg paracetamol , G4 drenched with 500 mg/kg paracetamol ,G5 drenched with 500 mg/kg green tea ) , the present study found the ability of green tea to protect liver enzyme against the poisonous effect of paracetamol by reducing the higher value of GPT,GOT, Glucose, and evaluated the lower value of Uric acid and total protein causing by paracetamol.