Author : TALAT ABBAS, MOHAMMED
karbala journal of pharmaceutical sciences,
Volume 5, Issue 7, Pages 227-237
The aim of this study is to evaluate the protective effect of camil milk on aspirin-induced oxidative stress in the liver of male albino rats. The current study included 24 male rats, which were divided into 4 groups, each group included 6 rats: group 1 as a control group, Group 2 was given aspirin at 100 mg/kg /day, orally via gavage ,Group 3 was given camil milk orally via gavage at 1 mL/kg/day and group 4 were given aspirin at 100 mg/kg/day and (after 3 hours) camil milk at 1 mL/kg/day, orally via gavage for 30 days. The results show significantly increase in serum aspartate aminotransferase and alanine aminotransferase activity, which is associated with histopathological damage of the liver. Aspirin increased oxidative stress through the increase in malodialdehyde level and decrease in superoxide dismutase , catalase and glutathione peroxidase enzymes. This modulation of the biological parameter histological damage is significantly neutralized by the administration of the camil milk. From which we can conduct that administer of the camil milk reduce the toxicity and damage caused by the aspirin.