ISSN: 7027-2221

Author : M. Fahmi, Zena


A comparative study on the fertility effects of phytochemical compounds isolated from the fruits of Euterpe Oleracea L. and Lycium Barbarum L. with Tadalafil drug on male rats

Alaa A. Abdulrasool; Zena M. Fahmi; Huda F. Hasan

karbala journal of pharmaceutical sciences, Volume 5, Issue 8, Pages 98-109

This study was implemented to investigate the effect of Euterpe. Oleracea L. anthocyanin (EOA) and L. barbarum polysaccharides (LBP) on male fertility in comparison with tadalafil. Anthrocyanin was obtained from the crude extract of E. oleracea using solid phase extraction (SPE). polysaccharides were isolated from the crude extract of Lycium barbarum L. using chemical methods. Twenty eight adult male rats were divided into four equal groups; First group (T1), was treated with 80 mg/kg (EOA). Second group (T2), was treated with 100 mg/kg (LBP), third group (T3), was treated with 1.8mg/kg Tadalafil drug. The last group (T4) was treated with distilled water and was considered as control group. Results of sperm (count, motility, and viability), testosterone level and fertility index of T1,T2 and T3 groups showed significant increase as compared with (T4). The (T2) was showed a significant decrease in the abnormality percentage and significant increase in testes weight and Gonadosomatic index as compared with (T4). The (T1) showed a significant reduction of the body, testes weight and gonadosomatic index as compared with (T4). The (T3) showed significant increase of the body, testes weight and gonadosomatic index as compared with (T4). Histological results of the testis in (T1) showed the somniferous tubules were filled with spermatid and mature spermatozoa, while (T2) had hyperplasia in few somniferous tubules in the primary spermatocytes and the somniferous tubules lumen was filled with mature spermatozoa, while (T3) revealed a clear congestion of blood vessels and odema in the interstitial tissue. In this study concluded the Polysaccharides of L. barbarum fruits and anthocyanins of E. oleracea fruit can be considered as fertility-facilitating agents and can reduce the sperm deformities.