Author : Tarek Hanoon, Dr.Imad
Determination of Homatropine Methylbromide Drug by Using of Manufactured Selective Membrane Electrodes
karbala journal of pharmaceutical sciences,
Volume 6, Issue 9, Pages 157-165
An accurate,sensitive, selective and reproducible method for quantification of
Homatropine methylbromide in pharmaceutical has been developed. This method is based
on construction of selective liquid membrane electrodes using phosphomolybdic acid
(PMA) as an active material and di-n-butylphthalate(DBPH) as a plasticizer and PVC as
matrix . The results showed that the liner concentration is 10⁻1 - 10-5 M. for electrod .
Correlation coefficient 0.991, detection limit is 2.5 × 10-8μg.ml-1 optimum pH range
2.4-3.6, and life time is 28 days and recovery not less than 99% .
This method was successfully applied for the determination of Homatropine methylbromide
in Riabasam tablet is not less than 99% and its (105.57%).