ISSN: 7027-2221

Author : Marouf Al-Azzawi, Ahlam

Synthesis Of Several New Cyclic Imides Linked To [3-Mercapto-5-(4ʹ-tolyl)-1,2,4-triazole]Moiety With Antibacterial Activity Study

Ahlam Marouf Al-Azzawi; Enas Khalil Jassem

karbala journal of pharmaceutical sciences, Volume 6, Issue 10, Pages 0-0

In this work a variety of new cyclic imides containing1,2,4-triazole ring
were synthesized via multisteps synthesis.In the first step,p-toluic acid was introduced
in esterification reaction with ethanol,producing compound[1]ethyl-4-methyl
benzoate.Introducing of compound [1]in reaction with hydrazine hydrate in the
second step afforded compound[2]4-tolyl acetohydrazide.Reaction of compound[2]
with carbon disulfide in alkaline medium followed by refluxing the product with
hydrazine hydrate afforded compound[3]3-mercapto-4-amino-5-(4ʹ-tolyl)-1,2,4-
triazole.Compound [3]was introduced in reaction with different cyclic anhydrides
producing a series of new amic acids[4-8]which subsequently were dehydrated via
treatment with acetic anhydride and anhydrous sodium acetate producing the
corresponding target imides [9-13]. Antibacterial activity study of the new imides
indicated that,they exhibit good inhibition activity againt the tested organisms.