ISSN: 7027-2221

Author : S. H. Alnuaimi, Maha

Synthesis and characterization of some new N-mannich bases for clonazepam

Maha S. H. Alnuaimi; Khalaf F Alsamarrai; Athraa Aameed jassim

karbala journal of pharmaceutical sciences, Volume 7, Issue 11, Pages 246-255

The N- Mannich bases (1-10) have been synthesized by reaction of clonazepam with
formaldehyde or benzaldehyde and different secondary amines. The N-Mannich bases
were subjected to physicochemical studies like melting point determination, TLC and
yield%. The structures of mannich bases were characterized by IR, 1HNMR and
13CNMR spectroscopy.