ISSN: 7027-2221

Author : Jawad Al-Tu, Fadhil

Relationship between Transforming Growth Factor-Beta 1 gene polymorphism and hypertension

Fadhil Jawad Al-Tu; Zena Abdul-Ameer Mahdi; Hassan Ali Nassrallah

karbala journal of pharmaceutical sciences, Volume 7, Issue 11, Pages 225-235

This study intends to evaluate the association between Transforming Growth Factor - Beta1
(TGF-β1) SNP codon 25 and hypertension in holy Kerbala city, Iraq. A case control study
for one hundred and four subjects. Seventy four hypertensive patients (23 male and 51
female), already diagnosed with essential hypertension, and 30 control subjects (16 male
and 14 female). The links between genotype and hypertension were examined then possible
SNP related variances in the blood pressure were checked. The present study suggested that
there is no significant association between transforming growth factor beta one (TGF-β1)
and hypertension in its Iraqi population sample. However, there is a significant association
between Arginine (Arg25) and hypertension compared with control group clearly shown in
the male gender (p < 0.05). In this study, the associations between the SNP of TGF-β1
codon 25 and hypertension was not significant while the SNP showed genotype-related
differences in gene allele (Arg25).