Author : A.K. Abutiheen, Ali
;hfChanges in serum potassium and serum creatinine in hypertensive patients treated with Captopril with or without amlodipine
karbala journal of pharmaceutical sciences,
Volume 7, Issue 11, Pages 192-201
Background. Renal function and serum potassium are affected by many drugs.
Angiotensin Converting Enzyme inhibitors and calcium channel blockers used to treat
hypertension and non steroidal anti-inflammatory drugs used for musculoskeletal
diseases. Those drugs affect both the renal function and the serum potassium. The aim
of this study was to find the impact of these drugs on the renal function and serum
Methods. A prospective study includes 60 patients in Al Hussain Teaching hospital
in Kerbala. Sixty patients were involved in this study 27 male and 33 female, their
age ranges between 41 and 65 years with a mean age of 52.98 years.
All patients had hypertension and 34 of them had diabetes mellitus also. All patients
started on captopril, 13 of them amlodipine added for them to control blood pressure,
and 11 used none steroidal anti-inflammatory drugs. Serum potassium and serum
creatinine were checked twice before starting treatment and the average value
recorded and checked again after 3 months. Physical examination was done during
the follow-up visits to look for symptoms and signs of hyperkalemia e.g. weakness,
fatigability, parasthesia, or areflexia. Electrographic recording done to look for
changes of hyperkalemia.
A significant increase in serum potassium and creatinine after starting treatment in
the whole group. Regard the gender there were significant differences in both the
serum potassium and serum creatinine in female patients but the differences were not
significant in male patients.
There was a significant difference in serum potassium in patients receiving captopril
alone but not in serum Creatinine. There was difference in serum potassium and
serum creatinine in the group of patients receiving captopril and amlodipine and
statistically were significant. Changes were significant in diabetic patients but not in
Conclusion. Captopril, amlodipine result in an increase in serum potassium and in
serum creatinine in patients treated for hypertension.