Author : Alhelfi, Abdulbari
karbala journal of pharmaceutical sciences,
Volume 7, Issue 11, Pages 15-25
Anew and simple sensitive reproducible spectrophotometric method was used for
determination of famotidine drug(FA) in bulk sample and pharmaceutical formulation
. The determination depend on formed the prussian blue by reacting the drug with
iron(III) chloride to form iron(II) which reacts with potassium hexacyanoferrate(III).
The product measurable spectrophotometrically at 744 nm. Regression analysis of
Beers plot good correlation in the concentration range (1.00-6.00) μg.ml-1
No interference was observed from the usually existing additive in the
pharmaceutical formulation and the applicability of the method was examined by
analyzing tablets containing (FA).
The correlation coefficient of 0.9982, a relative standard deviation (RSD%)of
(2.07%) and the detection limit was (3.50×10-5) μg.ml-1and the sandell sensitivity was
(1.70×10⁻⁴ μg.cm). Recoveries were (98.25-100.5 )% .