ISSN: 7027-2221

Author : Abdu Al Ruda, Zainab


A study of sICAM-1,sVCAM-1 and sE-Selectin Profile in type II diabetes and latent autoimmune diabetes of adult.

Sawsan M Jabbar Al-Hasnawi; Alaa Saad Al-Attabi; Zainab Abdu Al Ruda

karbala journal of pharmaceutical sciences, Volume 7, Issue 11, Pages 256-269

Intercellular adhesion molecule 1( ICAM-1) and vascular cell adhesion molecule
VCAM-1 are members of the immunoglobulin superfamily bind to other
members of the superfamily, to integrins or to a diverse range of additional
counter-receptors. E-selectin which is presented on endothelial cells when its
activated acutely. Serum levels of adhesion molecules like ICAM-1 measurement
are possible after shedding of these molecules from active surface of endothelial
cells and macrophages in diabetes patients following hyperglycemia as in patient
with LADA and type II diabetes mellitus .So that this study was done for
measuring serum level of ICAM-1,VCAM-1 and E-Selectin Profile in type II
diabetes and latent autoimmune diabetes of adult and study their relation with
level of HbA1C , gender , age ,BMI and complication of diabetes. In the study the
serum of 36 patients with type2 diabetes mellitus ,34 patients with LADA and
20 healthy subjects test by ELISA technique for measuring the level of ICAM-
1,VCAM-1 and E-selectin . The study resulted in the mean sVCAM-1level of
control group was significantly lower than D.M.2 and LADA group, P<0.05. The
sE- Selectin level was higher in LADA group than control and D.M. type 2
group & significantly different when compared to control group (P<0.05). The
sVCAM-1 level had a significant positive correlation (R=0.25, P=0.017) with
BMI in all groups. High level of (sICAM-1,sVCAM-1 and sE-Selectin ) are
associated with increased incidence of complication .