ISSN: 7027-2221

Author : Hasan Abdul-Qahar, Zina

Effect of thyroid peroxidase antibodies (TPO) on endometrium thickness (ET) - Ova size in infertile women in Kerbala a descriptive study

Mousa M. Ali Al-Alak; Zahraa Sabbar Omran; Zina Hasan Abdul-Qahar

karbala journal of pharmaceutical sciences, Volume 7, Issue 11, Pages 145-149

Infertility is a disease of the reproductive system defined by failure achieve a clinical pregnancy
or inability of a couple to conceive naturally after 12 months or more regular intercourse
without contraception. Thyroid dysfunction can lead to menstrual disturbance, anovulatory
cycle and decreased fertility. Autoimmune thyroid diseases are the most common autoimmune
conditions encountered in females in reproductive age characterized by presence of antibodies
against some structures of thyroid gland such as thyroid peroxidase (TPO); which is the key
thyroid enzyme catalyzing both the iodination and coupling reaction for the synthesis of thyroid
hormone. Anti-TPO autoantibodies are present in approximately 90% of patients with
autoimmune thyroid diseases.The study aimed to evaluate the role of thyroid antibodies in
subfertility patients on ova size and endometrium thickness. The study was conducted during
the period from March 2015 to September 2015 at Karbala Maternity Hospital, infertility unit,
and some private clinics. This study included a total number of 92 women in the reproductive
age; ranging between (15- 43) years; divided patients into: primary infertility included (56);
while secondary infertility were (36) infertility females. The following parameter were
measured for all study groups: anti-TPO using ELISA device .Additionally, ultrasound was
done to measure the ova size and endometrial thickness. The results showed a significant
difference between primary and secondary infertility in TPO, when relation between TPO with
ova size and endometrial thickness there is a significant difference between TPO and ova size in
abnormal TPO and a significant difference between TPO and ET in abnormal TPO in infertile
women. There is a relation between ova size and TPO, anti-TPO may be used as a biochemical
indicator of subclinical thyroid disorders and may help in assessment of thyroid function as a
cause of infertility whether primary or secondary.