Author : Al-Zubaidi, Dr.Riyadh
karbala journal of pharmaceutical sciences,
Volume 8, Issue 12, Pages 29-33
Diabetes is a long life condition that causes a person's blood sugar level to become too high. Type 2 diabetes occurs when the body doesn't produce enough insulin to function properly, or the body’s cells don't react to insulin. This means that glucose stays in the blood and isn't used as fuel for energy. The present study was conducted to investigate the serum total antioxidant capacity ,serum leptin ,blood glucose and lipid profile and its association with the type 2 diabetes mellitus. The study was case control conducted 55 male with Type II diabetes and 17 male volunteers were healthy control group, blood samples collected after 14 h fasting Parameters was measured with special enzymatic kits. The present study show significant decline of serum total antioxidant capacity among diabetic cases compared with control group (p< 0.001), serum lepton was and blood glucose significantly high in type 2 diabetes patients group compared with control group (P < 0.001) . Serum cholesterol, LDL-C and triglyceride were high but no significant in type 2diabetes patients group than normal control group (P < 0.001),while serum HDL-C level was lower non-significant in type 2diabetes patients than control group. We concluded the wasSignificant decline in serum total antioxidant and significant elevations in serum leptin intype2 diabetes in comparison with normal subjects.