Author : D. Aziz, Noor
karbala journal of pharmaceutical sciences,
Volume 8, Issue 13, Pages 278-287
Ureteral stent implantation is a common procedure in urological practice, due to the development in endourological procedures and extracorporeal shock wave lithotripsy.Problems following stent insertion such as stent-related symptoms, migration, fragmentation and encrustation of the stent. The level of complications differs among patients, but mostly it will affect quality of life.α1-Adrenergic receptors have been expressed in the human ureter, and specially in the distal ureter. α1 blockers dilate the lumen and decrease spasms leading to improve stent-related symptoms .The present study was done to evaluate the effect of tamsulosin in improving lower urinary tract symptoms in patients with double-J ureteral stents implantation.This prospective study was performed in Iraq-Babylon in the period from July 2016 to December 2016. Fourty eight patients were enrolled in this study all patients completed the follow up period which was 2 weeks, range of age was (25-50) years . The patients were divided into 2 groups: Group 1: consists of (24) patients include (10) males (14) females were treated with double J stent insertion and analgesic on need without Tamsulosin. Group 2: consists of (24) patients include (13) males (11) female were treated with double J stent insertion and drug therapy (tamsulosin 0.4 mg) daily(by oral rout) for 2 weeks. The results show that there was a significant improvement in lower urinary tract symptoms after the treatment period in the second group of patients (p0.01).In conclusion the use of tamsulosin 0.4 mg daily for 14 days is a safe and well tolerated for stent-related symptoms improvement.