Author : Mahmood, Hasanain
karbala journal of pharmaceutical sciences,
Volume 9, Issue 14, Pages 1-11
Background and aim: An orally disintegrating tablet (ODT) is different than ordinary tablets
since it was designed to be disintegrated in the mouth cavity rather than swallowed to
stomach. ODT has been used for elder, children and patients who have swallowing difficulty.
Lornoxicam is a non-steroidal anti-inflammatory drug which used as analgesic, anti-pyretic
and anti-inflammatory agent. Baclofen is used as a muscle relaxant; therefore, adding
baclofen to lornoxicam in the same dosage form unit could both help improve certain
musculoskeletal problems and improve patient compliance. The aim of this study was to
formulate ODT of lornoxicam/baclofen containing different amount and types of
Method: Ten formulas of lornoxicam/baclofen ODTs using different excipients and
superdisintegrants including crospovidone (CP), sodium starch glycolate (SSG),
croscarmellose (CC) and banana powder in different concentrations. Different evaluation
tests were performed for the tablet formulations involving tablet hardness, friability,
content uniformity, weight variation, thickness, tablet disintegration and dissolution test.
Results and conclusion: The results demonstrated that formula containing 5% of SSG has a
better formula with disintegration time of 15 seconds and better percent of drug release
reaching more than 99% of lornoxicam and more than 95% of baclofen after 45 minutes of
dissolution study. All formulas have acceptable results except tablets containing banana
powder since their disintegration times were more than 5 minutes.